Given the growing clinical pipeline of biologics and advantages offered by plant-derived therapeutics, such as high scalability and eukaryotic modification of proteins, plant-based expression systems have emerged as an optimal drug development platform
Roots Analysis has announced the addition of “Plant-based Biologics and Expression Systems Market, 2022-2035” report to its list of offerings.
Plants produce high-value recombinant proteins that can be used for the preparation of pharmaceutical therapeutics, as well as non-pharmaceutical products; these proteins find applications in the development of antibodies, vaccine antigens, enzymes, growth factors, research or diagnostic reagents and cosmetic ingredients. Plant-host engineering serves as a method for the production of proteins with distinct and uniform post-translational modifications (PTMs), creating opportunities for the development of biologics having relatively increased efficacy, as compared to their mammalian cell counterparts.
Key Market Insights
35+ players are currently engaged in offering plant-based expression systems
Close to 30% of the plant-based therapies are being developed by using benth as a protein expression host system. Other prominent plants used for the development of biologic drug candidates include tobacco, rice, wheat germ and tomato.
Over 40% of the plant-based expression system providers are based in North America
Within North America, the developer landscape is further dominated by players that are based in the US, representing around 30% of the total number of stakeholders located across the globe. Further, majority of companies (>65%) engaged in this market are small players (2-50 employees).
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More than 45 plant-based biologics have been / are being developed for the treatment of a range of clinical conditions
Over 45% of the aforementioned therapeutic candidates are under clinical evaluation, primarily being investigated in phase II studies. Examples of approved plant-based therapies include Elelyso® (developed by Protalix Biotherapeutics) and PALFORZIA® (developed by Aimmune Therapeutics).
Over 50% plant-based therapies have been / are being developed against infectious disorders
Currently, majority of such therapies (more than 35%) are being developed against the COVID-19 infection. It is also worth noting that close to 30% of the therapies have been / are being developed as vaccines.
Partnership activity in this field has increased at a CAGR of 16%, between 2018 and 2020
Interestingly, 35% of the reported deals were instances of R&D agreements, followed by licensing agreements (30%). Further, majority of the instances captured in the report were inked by players based in North America (over 50%).
>60% publications for plant-based biologics and expression systems are research articles
Close to 135 publications have received supporting grants from various organizations. Furthermore, we have conducted a proprietary timeline analysis to calculate the average number of days for a research article to move through the different steps of the process, from receiving acceptance of the authorizing organization to being published.
North America is anticipated to capture around 40% share of the global expression systems market in 2035
Around 55% of the market revenues are further expected to be generated through transient plant-based expression systems in 2035. Further, plant-based therapies developed as monoclonal antibodies are expected to occupy a larger share (25%) of the market, followed by vaccines (24%) and biosimilars (20%).
Plant-based therapies targeting infectious disorders are anticipated to capture around 35% of the global market share in 2035
Over 20% of the market revenues are expected to be generated from plant-based therapies being developed for the treatment of liver disorders, in 2035. This is followed by therapies being developed against respiratory disorders (~15%).
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Key Questions Answered
- Who are the key players engaged in providing plant-based expression systems?
- What are the key plant sources used by drug developers to manufacture plant-based biologics?
- Which are the key therapeutic areas for which plant-based biologics are being developed?
- What are the different proprietary technologies offered / developed by plant-based expression system providers?
- Which type of partnership models are most commonly adopted by stakeholders engaged in this domain?
- What is the relative competitiveness of different plant-based expression system providers?
- What is the evolving trend related to the focus of publications focused on plant-based biologics?
- How is the current and future market opportunity likely to be distributed across key market segments?
The financial opportunity within the plant-based expression systems and biologics market has been analyzed across the following segments:
Type of Product
- Biosimilars
- Cell Therapies
- Gene Therapies
- Monoclonal Antibodies
- Vaccines
- Others
Type of Plant
- Algae
- Barley
- Benth
- Duckweed
- Lettuce
- Maize
- Moss
- Rice
- Tomato
- Tobacco
- Wheat Germ
Type of Expression System
- Stable Expression System
- Transient Expression System
Type of Target Disease Indication
- Cirrhotic Ascites
- COVID-19
- Cystic Fibrosis
- Ebola Virus Infection
- Fabry Disease
- Gaucher Disease
- Liver Cirrhosis
- Influenza
- Peanut Allergy
Therapeutic Area
- Genetic Disorders
- Infectious Disorders
- Liver Disorders
- Respiratory Disorders
- Others
Drug Candidate
- Elelyso
- OsrHSA
- PALFORZIA
- PRX-110
- PRX-102
- Unnamed_1
- Unnamed_2
- ZMapp
Geographical Region
- North America
- Europe
- Asia
- Middle East and North Africa
- Latin America
- Rest of the World
The research includes profiles of key players (listed below); each profile features a brief overview of company, details related to its technology portfolio, recent developments (including collaborations and expansions) and an informed future outlook.
- medicago
- Leaf Expression Systems
- eleva
- iBio
- PlantForm
- G+Flas lifesciences
- Kentucky Bioprocessing
- Angany
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https://www.rootsanalysis.com/blog/at-home-blood-collection-new-era-of-diagnosis-and-testing/
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